Brain Metabolic Changes in Young vs Aged Rats During Hypoxia
نویسنده
چکیده
and neuropathology of cerebral "anoxic-ischemic" cell change. Arch Neurol 29: 367-374, 1973 20. Rice JE, Vannucci RC, Brierley JB: The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol 9: 131-141, 1981 21. Salford LG, Plum F, Siesjo BK: Graded hypoxia-oligemia in rat brain. Arch Neurol 29: 227-233, 1973 22. Levine S: Anoxic ischemic encephalopathy in rats. Am J Pathol 36: 1-17, 1960 23. Astrup J, Siesjo BK, Symon L: Thresholds of cerebral ischemia — the ischemic penumbra. Stroke 12: 723-725, 1981 24. Tate RL, Mehlman MA, Tobin RB: Metabolic fate of 1,3 butanediol in the rat: conversion to beta-hydroxybutarate. J Nutr 101: 1719-1726, 1971
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Brain metabolic changes in young vs aged rats during hypoxia.
Brain energy state and glycolytic metabolites were measured in young (6 month) and aged (28 month) male rats under normoxic (70% nitrous oxide, 30% oxygen) or hypoxic (PaO2 = 25 mm Hg) test conditions. Hypoxic ischemia was induced in one cerebral hemisphere by ligation of one carotid artery. Under normoxic test conditions brain energy metabolite concentrations were similar between young and age...
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